منابع مشابه
Emulating biology: building nanostructures from the bottom up.
The biological approach to nanotechnology has produced self-assembled objects, arrays and devices; likewise, it has achieved the recognition of inorganic systems and the control of their growth. Can these approaches now be integrated to produce useful systems?
متن کاملBright Building Blocks for Chemical Biology
Small-molecule fluorophores manifest the ability of chemistry to solve problems in biology. As we noted in a previous review (Lavis, L. D.; Raines, R. T. ACS Chem. Biol. 2008, 3, 142-155), the extant collection of fluorescent probes is built on a modest set of "core" scaffolds that evolved during a century of academic and industrial research. Here, we survey traditional and modern synthetic rou...
متن کاملBuilding up biology
In 2005, Thomas Knight declared that “biology will never be the same” in describing research from Drew Endy and colleagues that extended engineering terminology such as ‘refactoring’ and ‘parts’ to a biological context (Mol. Syst. Biol. 1, 2005.0020, 2005). By then, Elowitz’s and Leibler’s foundational ‘repressilator’ study, in which three transcriptional repressors were integrated into an arti...
متن کاملBottom-up synthetic biology: modular design for making artificial platelets.
Engineering artificial cells to mimic one or multiple fundamental cell biological functions is an emerging area of synthetic biology. Reconstituting functional modules from biological components in vitro is a challenging yet an important essence of bottom-up synthetic biology. Here we describe the concept of building artificial platelets using bottom-up synthetic biology and the four functional...
متن کاملChitosan microspheres with an extracellular matrix-mimicking nanofibrous structure as cell-carrier building blocks for bottom-up cartilage tissue engineering.
Scaffolds for tissue engineering (TE) which closely mimic the physicochemical properties of the natural extracellular matrix (ECM) have been proven to advantageously favor cell attachment, proliferation, migration and new tissue formation. Recently, as a valuable alternative, a bottom-up TE approach utilizing cell-loaded micrometer-scale modular components as building blocks to reconstruct a ne...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2018
ISSN: 0960-9822
DOI: 10.1016/j.cub.2018.07.010